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10:29
A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
Published on: March 24, 2017
[Modern antituberculosis treatment]
T Schaberg1, T Bauer, R Loddenkemper
1Zentrum für Pneumologie, Diakoniekrankenhaus Rotenburg, Elise-Averdiek-Str. 17, 27356 Rotenburg, Deutschland. schaberg@diako-online.de
Der Internist
|March 27, 2013
Summary
Tuberculosis (TB) is rare in Germany, leading to decreased clinical experience. This review details standard TB therapy, emphasizing drug resistance risk assessment and combined antibiotic treatment based on susceptibility testing.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Context:
- Tuberculosis (TB) incidence has significantly decreased in Germany, making it a rare disease.
- This decline results in diminishing clinical expertise in managing TB patients.
- Global TB estimates show 8.7 million new cases and 1.4 million deaths in 2011.
Purpose:
- To review standard tuberculosis therapy and associated drugs.
- To highlight the importance of risk assessment for drug-resistant TB.
- To outline diagnostic recommendations including bacterial confirmation and drug susceptibility testing.
Summary:
- Standard TB treatment involves combined antibiotic therapy.
- Drug selection is contingent upon the identified resistance patterns of the bacterial strains.
- Pre-treatment evaluation includes patient history for drug resistance risk factors and microbiological confirmation.
Impact:
- Provides essential guidance for healthcare professionals managing a rare disease.
- Supports adherence to current treatment recommendations from German authorities (DZK, DGP).
- Aims to maintain effective TB management despite decreasing incidence.
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