Related Experiment Video
Updated: May 12, 2026

A Modified Transcranial Middle Cerebral Artery Occlusion Model to Study Stroke Outcomes in Aged Mice
Published on: May 5, 2023
Stroke in centenarians.
Tom Skyhøj Olsen1, Klaus Kaae Andersen
1The Stroke Unit, Frederiksberg University Hospital, Frederiksberg, Denmark.
Centenarians experiencing stroke have fewer cardiovascular risk factors but face more severe strokes and significantly higher mortality within one month. This study highlights the unique challenges of stroke in the oldest population.
Area of Science:
- Gerontology
- Neurology
- Epidemiology
Background:
- Stroke incidence increases with age.
- Centenarians represent a unique demographic for studying age-related health outcomes.
- Limited data exists on stroke characteristics in centenarians.
Purpose of the Study:
- To describe clinical features of acute stroke in centenarians.
- To determine 1-month mortality rates in centenarians with stroke.
- To compare centenarians with younger stroke patient cohorts.
Main Methods:
- Retrospective analysis of a Danish stroke registry (2000-2010).
- Inclusion of 39 centenarian stroke patients.
- Comparison with stroke patients aged 40-99 years, analyzing demographics, stroke severity (Scandinavian Stroke Scale), risk factors, and mortality.
Main Results:
- Centenarian stroke patients were predominantly women (87%) and lived alone (82%).
- Lower prevalence of cardiovascular risk factors (myocardial infarction, diabetes) was observed.
- Strokes were more severe (SSS 25.4) with significantly higher 1-month mortality (38.5%) compared to younger groups.
Conclusions:
- Centenarians with stroke may have better cardiovascular health prior to the event.
- Despite this, strokes in centenarians are more severe.
- Stroke in centenarians is associated with a very high short-term mortality risk.
More Related Videos
Related Concept Videos
Hemorrhagic Stroke l: Introduction
Stroke: Introduction and Types
Ischemic Stroke l: Introduction
Hemorrhagic Stroke ll: Pathophysiology
Ischemic Stroke ll: Pathophysiology
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...

