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Delivery of In Vivo Acute Intermittent Hypoxia in Neonatal Rodents to Prime Subventricular Zone-derived Neural Progenitor Cell Cultures
Published on: November 2, 2015
Hypoxia-induced phrenic long-term facilitation: emergent properties.
Michael J Devinney1, Adrianne G Huxtable, Nicole L Nichols
1Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Annals of the New York Academy of Sciences
|March 28, 2013
Summary
Respiratory plasticity, like phrenic long-term facilitation (pLTF), involves distinct Q and S pathways. Their interaction may confer emergent properties, potentially optimizing treatments for ventilatory impairment.
Area of Science:
- Neuroscience
- Respiratory Physiology
- Cellular Signaling
Background:
- Neural plasticity, specifically phrenic long-term facilitation (pLTF), is crucial for breathing control.
- pLTF is induced by acute intermittent hypoxia and involves cellular mechanisms within the phrenic motor nucleus.
- Different signaling cascades, termed Q and S pathways, mediate pLTF under varying conditions.
Purpose of the Study:
- To explore the interaction between the Q and S pathways of phrenic motor facilitation (pMF).
- To investigate the biological significance of multiple pathways contributing to pLTF.
- To discuss how pathway interactions might confer emergent properties like pattern sensitivity and metaplasticity.
Main Methods:
- Review of existing literature on respiratory plasticity and phrenic long-term facilitation.
- Analysis of signaling cascades (Q and S pathways) involved in pLTF.
- Discussion of cross-talk inhibition between Q and S pathways.
Main Results:
- The Q pathway primarily mediates pLTF after mild to moderate hypoxia.
- The S pathway primarily mediates pLTF after severe hypoxia.
- These pathways interact through cross-talk inhibition.
Conclusions:
- Interactions between Q and S pathways may lead to emergent properties in pLTF, such as pattern sensitivity and metaplasticity.
- Understanding these complex mechanisms is vital for developing optimized intermittent hypoxia-based treatments.
- Potential applications include treating patients with ventilatory impairment or other motor deficits.
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