Related Experiment Video
Updated: May 12, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Nutrient-based dietary patterns of head and neck squamous cell cancer: a factor analysis in Uruguay
Hugo Deneo-Pellegrini1, Paolo Boffetta, Eduardo De Stefani
1Epidemiology Group, Department of Pathology, School of Medicine, Avenida Brasil 3080 department 402, 11300, Montevideo, Uruguay.
Objective:
The aim of this study was to investigate the association between nutrient-based dietary patterns and squamous cell cancers of the head and neck.
Methods:
We used a case-control study which included 548 cases and 548 controls. From these participants, we derived 23 nutrients and they were then submitted to a factorability analysis in order to conduct a principal component factor analysis.
Results:
We were able to identify four nutrient-derived patterns. The first pattern (meat-based pattern) was positively associated with squamous cell cancer of the head and neck (OR 2.85, 95 % CI 1.81-4.15), whereas the third pattern (fruit-based) was strongly protective (OR 0.43, 95 % CI 0.27-0.63). The other nutrient patterns were also significantly associated with head and neck squamous cell carcinoma with minor ORs.
Conclusion:
Both patterns suggest that red meat and fruits are major factors in the etiology of head and neck squamous cell cancer, replicating previous studies in the field.
Related Concept Videos
Cancer Prevention
Some...
Cancer Prevention
Some...
Cancer Survival Analysis
Urinary Tract Calculi IV: Nutrition Therapy and Prevention
Assessment of the Gastrointestinal System II: Health Perception Pattern
Health Perception Patterns
Health perception patterns offer valuable insights into a patient's lifestyle habits and how they may impact their GI health. These patterns include:
Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...