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Related Experiment Video

Updated: May 12, 2026

Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice
07:55

Echocardiographic Characterization of Left Ventricular Structure, Function, and Coronary Flow in Neonate Mice

Published on: April 7, 2022

Myocardial function in premature infants: a longitudinal observational study.

Beate Horsberg Eriksen1, Eirik Nestaas, Torstein Hole

  • 1Department of Paediatrics, Møre and Romsdal Hospital Trust, Ålesund Hospital, Ålesund, Norway.

BMJ Open
|March 28, 2013
PubMed
Summary

Atrioventricular tissue Doppler velocities in premature infants increase with age, correlating with gestational and postnatal age. Right ventricle function matures more rapidly than left ventricle function.

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Area of Science:

  • Neonatal cardiology
  • Pediatric echocardiography
  • Fetal and neonatal physiology

Background:

  • Myocardial function in premature infants is influenced by gestational and chronological age.
  • Longitudinal assessment of cardiac function is crucial during neonatal transition.
  • Atrioventricular tissue Doppler imaging provides insights into myocardial performance.

Purpose of the Study:

  • To investigate longitudinal changes in atrioventricular tissue Doppler velocities in premature infants.
  • To assess these changes during the neonatal transitional period and at expected term.
  • To evaluate the reproducibility of these echocardiographic measurements.

Main Methods:

  • Prospective, observational, longitudinal cohort study.
  • Involved 55 premature infants (gestational age 31-35 weeks).

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Last Updated: May 12, 2026

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  • Pulsed-wave atrioventricular annulus tissue Doppler velocities (S', E', A') measured on days 1, 2, 3, and at expected term.

    • Main Results:

    • All measured velocities significantly increased from the neonatal period to expected term (p<0.001).
    • Gestational age and postnatal age correlated significantly with several tissue Doppler velocities.
    • Right ventricle velocities showed a more pronounced increase with maturation compared to left ventricle velocities.

    Conclusions:

    • Atrioventricular tissue Doppler velocities in premature infants are associated with gestational and postnatal age, and ventricular size.
    • Postnatal maturation leads to greater increases in right ventricle velocities than left ventricle velocities.
    • The degree of E'/A' fusion impacts diastolic tissue Doppler velocities and requires reporting.