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Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Related Experiment Video

Updated: May 12, 2026

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

MicroRNAs in Cerebral Ischemia.

Yang Wang¹, Yongting Wang, Guo-Yuan Yang

¹Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China ; Neuroscience and Neuroengineering Research Center, Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.

Stroke Research and Treatment

|March 28, 2013

Summary

MicroRNAs (miRNAs) are key regulators in stroke development and potential biomarkers for cerebral ischemia. This overview discusses their function, clinical applications, and future prospects in stroke research.

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Last Updated: May 12, 2026

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Ischemic stroke risk significantly increases with age, leading to substantial mortality and disability worldwide.
Genes, RNAs, and proteins are implicated in stroke pathogenesis.
MicroRNAs (miRNAs), short noncoding RNAs, regulate gene expression and are involved in ischemic preconditioning and postconditioning.

Purpose of the Study:

To provide an overview of microRNA expression and function in the brain.
To explore the role of miRNAs as biomarkers in cerebral ischemia.
To discuss the clinical applications and limitations of miRNAs in stroke management.

Main Methods:

Literature review of studies on miRNAs in stroke.
Analysis of miRNA expression and function in the context of cerebral ischemia.
Examination of current and potential clinical applications of miRNAs.

Main Results:

miRNAs play a crucial role in the pathological processes of stroke.
miRNAs are involved in regulating responses to ischemic events in the brain.
miRNAs show potential as diagnostic and prognostic biomarkers for stroke.

Conclusions:

miRNAs are significant regulators in brain ischemia and hold promise for clinical applications.
Further research is needed to overcome limitations and fully realize the therapeutic potential of miRNAs in stroke.