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Updated: May 12, 2026
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
[Systemic lupus erythematosus and pregnancy].
Teresa Diniz-da-Costa1, Mónica Centeno, Luísa Pinto
1Departamento de Obstetrícia, Ginecologia e Medicina da Reprodução, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.
Acta Medica Portuguesa
|March 29, 2013
Summary
Systemic lupus erythematosus (SLE) in pregnancy requires careful management. Preconceptional remission and multidisciplinary care improve outcomes for mothers and babies.
Area of Science:
- Rheumatology and Immunology
- Obstetrics and Gynecology
Context:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease disproportionately affecting women of childbearing age.
- Pregnancy in SLE patients presents risks for maternal, obstetrical, and fetal complications.
Purpose:
- To review the key aspects of managing Systemic lupus erythematosus (SLE) during pregnancy.
- To emphasize the importance of preconceptional assessment and multidisciplinary care for optimizing pregnancy outcomes in SLE patients.
Summary:
- Optimal outcomes for SLE pregnancies are achieved when the disease is quiescent for at least six months prior to conception.
- Preconceptional management is vital for disease remission and therapy adjustment.
- Close monitoring of maternal health and fetal development by a tertiary care multidisciplinary team is essential.
- Specific risk factors for adverse pregnancy outcomes include antiphospholipid syndrome, anti-SSA/Ro or anti-SSB/LA antibodies, hypertension, and renal involvement.
Impact:
- Highlights the critical role of proactive management in improving maternal and fetal prognosis in SLE pregnancies.
- Underscores the necessity of a collaborative healthcare approach involving obstetricians, rheumatologists, nephrologists, and pediatricians.
- Provides a comprehensive overview for clinicians managing SLE patients planning or undergoing pregnancy.
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