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Related Concept Videos

Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
Accessory Structures of the Skin: Sweat Glands01:20

Accessory Structures of the Skin: Sweat Glands

Sweat glands or sudoriferous glands are one of the important accessory structures of the skin. They are small, coiled tubular structures located in the dermis, the middle layer of the skin. Sweat glands are responsible for producing and secreting sweat, a watery fluid that helps regulate body temperature and excrete waste products.
Sweat glands are classified as merocrine glands; that is, the secretions are excreted by exocytosis through a duct without affecting the cells of the gland. There...
Exocrine Glands: Methods of Secretion01:08

Exocrine Glands: Methods of Secretion

Exocrine glands are those that release their secretions through ducts. Based on their mode of secretion, they can be classified into merocrine, apocrine, and holocrine.
Merocrine Secretion
Merocrine secretion is the most common type of exocrine secretion. The secretions are enclosed in vesicles and moved to the cell's apical surface, where the contents are released by exocytosis. For example, mucous, a watery secretion rich in the glycoprotein mucin, is a merocrine secretion. The eccrine glands...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
The Mammary Glands01:12

The Mammary Glands

The female breast is a hemispheric projection of variable size positioned anterior to the pectoralis major and serratus anterior muscles. A fascia layer composed of dense, irregular connective tissue connects it to these muscles.
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
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Updated: May 12, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

[Eccrine poroma].

M M Leijs1, H F Merk, M Megahed

  • 1Klinik für Dermatologie und Allergologie, RWTH Universität Aachen, Pauwelsstr. 30, 52074 Aachen, Germany. mleijs@ukaachen.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|March 29, 2013
PubMed
Summary
This summary is machine-generated.

This case report details a rapidly growing cheek nodule in a 42-year-old man, diagnosed as an eccrine poroma. This rare sweat gland tumor highlights the importance of considering diverse differential diagnoses in dermatology.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Eccrine poromas are rare benign neoplasms originating from the intraepidermal portion of the eccrine sweat duct.
  • While typically slow-growing, rapid proliferation can occur, necessitating accurate diagnosis.
  • Differential diagnoses for facial nodules include various benign and malignant lesions.

Observation:

  • A 42-year-old male presented with a rapidly enlarging, asymptomatic (except for mild itching) nodule on his right cheek.
  • The lesion was surgically excised with a 3-4 mm safety margin.
  • Clinical considerations included pyogenic granuloma, amelanotic melanoma, basal cell carcinoma, and eccrine poroma.

Findings:

  • Histopathological examination confirmed the diagnosis of eccrine poroma.
  • The etiology of eccrine poroma is not fully understood, with potential contributing factors including hormonal influences, trauma, immunosuppression, and radiation exposure.

Implications:

  • This case underscores the importance of considering rare sweat gland tumors in the differential diagnosis of facial neoplasms.
  • Prompt surgical excision with adequate margins is crucial for managing eccrine poromas.
  • Further research into the pathophysiology of eccrine poromas may improve understanding and treatment strategies.