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Updated: May 12, 2026

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
Published on: April 16, 2012
Human T regulatory cells: on the way to cognition
Maciej Kaczorowski1, Marek Jutel
1Department of Clinical Immunology, Wroclaw Medical University, Wroclaw, Poland.
Abstract:
Forkhead box P3 (Foxp3)(+) T regulatory (Treg) cells are powerful controllers of the immune response and their role in the human immune system is indispensable. Since a number of revolutionary and very convincing results were brought to light, Foxp3 has unquestionably been thought to be the "master regulator" of Treg lineage commitment. Herein, we depict the revised view on the role of Foxp3 transcription factor, challenging this theory, as well as the growing significance of Runt-related transcription factor (RUNX) family proteins for Treg lineage. The review presents the current notion of Treg cell heterogeneity, molecular characteristics and their mechanisms of action.
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