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Updated: May 12, 2026
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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
[Tumor necrosis factor alpha-238G/A polymorphism and tuberculosis susceptibility: a meta-analysis]
Zhi-jiao Zhang1, Hang Zhu, Xu-di Pu
1Chongqing Medical University, Chongqing, China.
Summary
This meta-analysis found no significant link between the tumor necrosis factor (TNF) -238G/A gene polymorphism and tuberculosis susceptibility. The findings suggest this specific genetic variant does not influence the risk of developing tuberculosis.
Area of Science:
- Genetics
- Immunology
- Infectious Diseases
Context:
- Tuberculosis (TB) is a significant global health challenge.
- Genetic factors may influence individual susceptibility to TB.
- The tumor necrosis factor (TNF) gene is a key regulator of immune responses and has been implicated in TB pathogenesis.
Purpose:
- To conduct a comprehensive meta-analysis investigating the association between the TNF -238G/A polymorphism and tuberculosis susceptibility.
- To synthesize evidence from multiple case-control studies to determine the overall effect of this genetic variant on TB risk.
Summary:
- A meta-analysis of nine case-control studies was performed.
- No significant association was found between the TNF -238G/A polymorphism and tuberculosis susceptibility across various genetic models.
- Sensitivity analyses confirmed the robustness of these findings, with no significant heterogeneity or publication bias detected.
Impact:
- This study provides robust evidence that the TNF -238G/A polymorphism is unlikely to be a major determinant of tuberculosis susceptibility.
- The findings contribute to understanding the genetic landscape of TB and may inform future research into host-pathogen interactions.
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