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Related Concept Videos

Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Bone Disorders01:29

Bone Disorders

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Major Hormones and Their Functions01:27

Major Hormones and Their Functions

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Related Experiment Video

Updated: May 12, 2026

Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making
11:51

Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making

Published on: March 2, 2011

Testosterone and mood in aging men.

Stuart N Seidman1, Mark Weiser

  • 1West End Medical Associates, 617 West End Avenue, New York, NY 10024, USA. stuart.seidman@yahoo.com

The Psychiatric Clinics of North America
|March 30, 2013
PubMed
Summary
This summary is machine-generated.

Low testosterone in aging men, or hypogonadism, is linked to various health issues. Testosterone replacement therapy may improve mood and combat age-related depression in older men.

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Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

Area of Science:

  • Endocrinology
  • Gerontology
  • Neuroscience

Background:

  • Aging is associated with hypothalamic-pituitary-gonadal (HPG) axis hypofunction, leading to partial androgen deficiency in males.
  • This age-related decline, termed partial androgen deficiency of the aging male, is implicated in conditions like reduced muscle/bone mass, frailty, obesity, cognitive impairment, sexual dysfunction, and depression.

Purpose of the Study:

  • To explore the relationship between testosterone levels and mood in older men.
  • To review the efficacy of exogenous testosterone treatment for age-related depression.

Main Methods:

  • Review of existing literature on testosterone levels, aging, and mood disorders.
  • Analysis of studies investigating testosterone replacement therapy in aging males.

Main Results:

  • Establishing direct correlations between plasma testosterone and specific symptoms in middle-aged men has been challenging.
  • Testosterone replacement therapy has demonstrated benefits in improving muscle strength, bone density, and sexual function.

Conclusions:

  • Testosterone plays a role in mood regulation in older men.
  • Exogenous testosterone may be a viable treatment option for depression associated with aging and androgen deficiency.