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Updated: May 12, 2026
09:38
Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
Genetics of Alzheimer disease
A T Rao1, A J Degnan, L M Levy
1From the George Washington University Medical Center (A.T.R., L.M.L.), Washington, DC.
AJNR. American Journal of Neuroradiology
|March 30, 2013
Summary
Alzheimer disease (AD) is a leading cause of elderly disability, affecting 1 in 8 over 65. Both genetic and environmental factors, including family history and metabolic diseases, contribute to its development.
Area of Science:
- Neuroscience
- Gerontology
- Public Health
Background:
- Alzheimer disease (AD) is the most common dementia, significantly impacting the elderly population.
- It affects 1 in 8 individuals over 65, leading to widespread disability.
- Late-onset AD is influenced by a complex interplay of genetic and environmental factors.
Purpose of the Study:
- To summarize the prevalence and risk factors associated with Alzheimer disease.
- To highlight the contribution of genetic and environmental influences on AD development.
- To underscore the significance of inherited factors in both familial and sporadic AD cases.
Main Methods:
- Literature review of epidemiological data on Alzheimer disease.
- Analysis of twin studies to determine the role of inheritance.
- Identification of key risk factors including age, family history, brain injury, and metabolic conditions.
Main Results:
- Alzheimer disease is a primary cause of disability in older adults.
- Risk factors include advanced age, family history, brain trauma, and metabolic diseases like diabetes.
- Inheritance is a significant factor, implicated in approximately 80% of AD cases.
Conclusions:
- Alzheimer disease is a multifactorial condition with substantial genetic predisposition.
- Understanding risk factors is crucial for prevention and management strategies.
- Further research into genetic and environmental interactions is warranted.
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