Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mesenchymal Stem Cells

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

Adult Stem Cells

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evolving Landscape of Glioblastoma Research: Integrating Therapeutic Advances and Diagnostic Frontiers.

Brain sciences·2026

Same author

Editorial: Role of induced pluripotent stem cells (iPSCs) in regenerative medicine, disease modeling and drug discovery.

Frontiers in bioengineering and biotechnology·2025

Same author

The Relevance of Governance, External Monitoring, and Instructional Quality to Public-Private School Differences in Student Achievement in the Western Chitwan Valley of Nepal: An Exploratory Analysis.

International journal of educational development·2025

Same author

Oncogenic effects of ECM remodeling in obesity and breast cancer.

Oncogene·2025

Same author

Adipose Stromal Cell Heterogeneity and Trafficking: Implications for Breast Cancer Metastasis and Obesity.

Frontiers in bioscience (Landmark edition)·2025

Same author

Macrophage phenotypes modulate neoangiogenesis and fibroblast profiles in synovial-like organoid cultures.

Osteoarthritis and cartilage·2025

Same journal

TRABD2A promotes osteogenic differentiation of human periodontal ligament stem cells by modulating TNF-α and IL-1β.

Organogenesis·2026

Same journal

Thyroid cancer-derived exosomal SPP1 promotes tumor progression by driving macrophage M2 polarization through the CD44/JAK2/STAT3 signaling pathway.

Organogenesis·2026

Same journal

MLPH/RAB3A accelerates the differentiation of pancreatic stem cells to islet β-cells to control blood glucose in diabetic rats.

Organogenesis·2026

Same journal

Adipose-derived mesenchymal stem cells-derived exosomes containing nano-pearl powder water-soluble matrix promote osteogenic differentiation of MC3T3-E1 cells.

Organogenesis·2026

Same journal

Comparison of vascular remodeling between a bioresorbable poly-L-lactic acid scaffold and a bare metal stent: a 6-month angiography and intravascular ultrasound analysis in porcine iliac arteries.

Organogenesis·2026

Same journal

Optimization of TX-100/SDS-based decellularized vascular material using ultrasound and chemical treatment: evaluation of structure and biosafety.

Organogenesis·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 12, 2026

Isolation and Enrichment of Human Adipose-derived Stromal Cells for Enhanced Osteogenesis

Isolation and Enrichment of Human Adipose-derived Stromal Cells for Enhanced Osteogenesis

Published on: January 12, 2015

Adipose-derived stromal/stem cells: a primer.

Jeffrey M Gimble¹, Bruce A Bunnell, Trivia Frazier

¹Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.

|March 30, 2013

Summary

This summary is machine-generated.

Adipose stromal/stem cells are multipotent cells with therapeutic potential. These cells can differentiate and secrete factors, offering promise for regenerative medicine and immunomodulation in various disease states.

Keywords:

Adipokine Adipose Stromal/stem Cells Experimental Autoimmune Encephalitis Hematopoietic Stem and Progenitor Cell Mesenchymal Stem Cell or Multipotent Stromal Cell Progressive Osseous Heteroplasia

More Related Videos

Manual Isolation of Adipose-derived Stem Cells from Human Lipoaspirates

Manual Isolation of Adipose-derived Stem Cells from Human Lipoaspirates

Published on: September 26, 2013

Technique for Obtaining Mesenchymal Stem Cell from Adipose Tissue and Stromal Vascular Fraction Characterization in Long-Term Cryopreservation

Technique for Obtaining Mesenchymal Stem Cell from Adipose Tissue and Stromal Vascular Fraction Characterization in Long-Term Cryopreservation

Published on: December 30, 2021

Related Experiment Videos

Last Updated: May 12, 2026

Isolation and Enrichment of Human Adipose-derived Stromal Cells for Enhanced Osteogenesis

Isolation and Enrichment of Human Adipose-derived Stromal Cells for Enhanced Osteogenesis

Published on: January 12, 2015

Manual Isolation of Adipose-derived Stem Cells from Human Lipoaspirates

Manual Isolation of Adipose-derived Stem Cells from Human Lipoaspirates

Published on: September 26, 2013

Technique for Obtaining Mesenchymal Stem Cell from Adipose Tissue and Stromal Vascular Fraction Characterization in Long-Term Cryopreservation

Technique for Obtaining Mesenchymal Stem Cell from Adipose Tissue and Stromal Vascular Fraction Characterization in Long-Term Cryopreservation

Published on: December 30, 2021

Area of Science:

Stem Cell Biology
Regenerative Medicine
Endocrinology

Background:

Adipose tissue complexity and physiological roles were underestimated until adipokine discovery.
Adipose tissue cellular composition is heterogeneous and influenced by disease states like diabetes.

Purpose of the Study:

To review the mechanisms of adipose stromal/stem cell action.
To explore the potential of adipose stromal/stem cells as cellular therapeutics.

Main Methods:

Isolation of adult stromal/stem cells from adipose tissue via collagenase digestion.
In vitro and in vivo studies to assess multipotency and differentiation potential.
Analysis of secreted cytokines, growth factors, and immunomodulatory functions.

Main Results:

Adipose stromal/stem cells are multipotent, differentiating into adipocytes, chondrocytes, and osteoblasts.
These cells secrete various cytokines and growth factors with paracrine effects.
Adipose stromal/stem cells exhibit immunomodulatory functions, enabling allogeneic transplantation.

Conclusions:

Adipose stromal/stem cells possess significant therapeutic potential due to their differentiation capacity and secretory functions.
Their immunomodulatory properties suggest suitability for allogeneic transplantation in regenerative medicine applications.