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The frequency of poststroke infections and their impact on early stroke outcome

Natasa Popović1, Maja Stefanović-Budimkić, Nikola Mitrović

  • 1Clinic for Infectious and Tropical Diseases, Clinical Center of Serbia, Belgrade, Serbia.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|April 2, 2013
PubMed
Abstract

Insights

Poststroke infections are common and significantly increase the risk of poor functional outcomes and death. Urinary tract infections (UTIs) are a major contributor to these adverse events following stroke.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Poststroke infections are frequent complications, affecting up to 65% of patients.
  • Infections can significantly worsen patient outcomes after stroke.

Purpose of the Study:

  • To determine the incidence of infectious complications in hospitalized stroke patients.
  • To evaluate the impact of infections, including UTIs, pneumonia, and sepsis, on stroke outcomes.

Main Methods:

  • Retrospective analysis of acute ischemic stroke patients over a 1-year period.
  • Definition of poor functional outcome: modified Rankin Scale score of 3-5.
  • Univariate and multivariate logistic regression analyses were employed.

Main Results:

  • 47.4% of patients developed poststroke infections; UTIs were most common (20.3%).
  • Infection independently predicted poor functional outcome (OR 12.82) and death (OR 14.92).
  • UTIs independently predicted poor functional outcome (OR 14.08) and death (OR 9.81).

Conclusions:

  • Infection is a frequent complication after stroke.
  • Poststroke infection is an independent predictor of poor functional and fatal early outcomes.

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