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Related Concept Videos

Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

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Updated: May 12, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
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Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

Dasatinib-induced nephrotic-range proteinuria.

Eric Wallace1, William Lyndon, Phillip Chumley

  • 1Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL, USA. ericlwallace@uab.edu

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|April 2, 2013
PubMed
Summary
This summary is machine-generated.

Tyrosine kinase inhibitors (TKIs) like dasatinib can cause kidney damage, including nephrotic-range proteinuria. Switching to imatinib resolved the patient's kidney injury, highlighting the need for nephrologists to monitor TKI side effects.

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07:38

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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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Published on: July 3, 2013

Area of Science:

  • Oncology
  • Nephrology
  • Pharmacology

Background:

  • Tyrosine kinase inhibitors (TKIs) are crucial in treating malignancies, targeting specific kinases.
  • The expanding use of TKIs necessitates understanding their potential off-target effects on kidney function.
  • Nephrologists must be aware of and manage TKI-induced kidney pathologies.

Observation:

  • A patient with chronic myelogenous leukemia developed nephrotic-range proteinuria after starting dasatinib.
  • The proteinuria resolved upon discontinuation of dasatinib and initiation of imatinib therapy.
  • This case highlights a previously undescribed mechanism of kidney injury associated with dasatinib.

Findings:

  • Dasatinib therapy was associated with the development of nephrotic-range proteinuria.
  • Switching to imatinib led to the resolution of proteinuria, suggesting a drug-specific effect.
  • The study reviews the role of vascular endothelial growth factor (VEGF) in kidney pathology related to TKI therapy.

Implications:

  • This case underscores the importance of vigilant renal monitoring in patients receiving TKIs.
  • Understanding the mechanisms of TKI-induced kidney injury is crucial for appropriate management.
  • Further research into the specific nephrotoxic pathways of drugs like dasatinib is warranted.