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Updated: May 12, 2026

Determining Bile Duct Density in the Mouse Liver
Published on: April 30, 2019
Alagille syndrome and other hereditary causes of cholestasis
Jane L Hartley1, Paul Gissen, Deirdre A Kelly
1Liver Unit, Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK.
Abstract:
Neonatal conjugated jaundice is a common presentation of hereditary liver diseases, which, although rare, are important to recognize early. Developments in molecular genetic techniques have enabled the identification of causative genes, which has improved diagnostic accuracy for patients and has led to a greater understanding of the molecular pathways involved in liver biology and pathogenesis of liver diseases. This review provides an update of the current understanding of clinical and molecular features of the inherited liver diseases that cause neonatal conjugated jaundice.
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