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Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography
Published on: February 9, 2019
Optical coherence tomography for rapid tissue screening and directed histological sectioning.
Woonggyu Jung1, Stephen A Boppart
1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Studies in Health Technology and Informatics
|April 2, 2013
Summary
Optical coherence tomography (OCT) offers high-resolution, real-time tissue imaging, addressing histology
Area of Science:
- Pathology
- Medical Imaging
- Biomedical Engineering
Background:
- Histological examination is the gold standard for disease diagnosis.
- Histology has limitations including lack of real-time in vivo observation and sampling errors.
- There is a need for advanced imaging techniques to complement or replace traditional histology.
Purpose of the Study:
- To review the application of Optical Coherence Tomography (OCT) in pathology.
- To highlight OCT's potential as an image guidance tool for rapid tissue screening.
- To discuss OCT's role in directed histological tissue sectioning.
Main Methods:
- Review of existing literature on OCT in pathology.
- Description of OCT's capabilities for real-time, high-resolution, cross-sectional imaging.
- Discussion of OCT's advantages over traditional histological methods.
Main Results:
- OCT provides high-resolution imaging comparable to histology.
- OCT enables real-time, in vivo tissue observation, overcoming sampling errors.
- OCT can guide rapid tissue screening and targeted biopsies.
Conclusions:
- OCT is a promising imaging modality for pathology.
- OCT can serve as an adjunct to histology, especially when rapid screening or large area investigation is needed.
- OCT facilitates non-destructive, high-resolution, and fast tissue assessment.
