WREstimates: An R Package for Win-Ratio Sample Size and Power Calculations

The win-ratio has great potential for determining the overall efficacy of treatments and therapies in clinical trials, as its ability to hierarchically account for multiple endpoints provides a holistic metric of the treatment effect. For the win-ratio to become a prominent and reliable statistical method outside of cardiovascular disease, a straightforward approach to study design, particularly in terms of power and sample size determination, is needed.

Using an appropriate method for determining these metrics is vital to ensure the validity of the results obtained in a study.

The WRestimates package provides easy-to-use functions that can be used for determining the required sample size and power of studies implementing the win-ratio.

These methods enable the calculation of sample size and power based on estimands or pilot data, thereby eliminating the need for complex simulation-based methods that require numerous assumptions about the data.