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Updated: May 12, 2026

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

Artichoke leaf extract for treating hypercholesterolaemia.

Barbara Wider1, Max H Pittler, Joanna Thompson-Coon

  • 1Institute of Health Services Research, University of Exeter Medical School, Exeter, UK. b.wider@exeter.ac.uk

The Cochrane Database of Systematic Reviews
|April 2, 2013
PubMed
Summary
This summary is machine-generated.

Artichoke leaf extract (ALE) shows potential for lowering cholesterol levels in hypercholesterolaemia patients. However, current evidence is not yet convincing, and further research is needed to confirm its efficacy and safety.

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Cholesterol Efflux Assay
07:54

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Published on: March 6, 2012

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Last Updated: May 12, 2026

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11:06

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Cholesterol Efflux Assay
07:54

Cholesterol Efflux Assay

Published on: March 6, 2012

Area of Science:

  • Cardiovascular Health
  • Phytotherapy
  • Evidence-Based Medicine

Background:

  • Hypercholesterolaemia significantly increases the risk of coronary heart disease and atherosclerosis.
  • Artichoke leaf extract (ALE) is a potential natural remedy for managing cholesterol levels.
  • The efficacy of ALE for hypercholesterolaemia requires further investigation.

Purpose of the Study:

  • To evaluate the effectiveness and safety of Artichoke Leaf Extract (ALE) in treating hypercholesterolaemia.
  • This review is an update of previous assessments conducted in 2002 and 2009.

Main Methods:

  • Systematic search of multiple databases including CENTRAL, MEDLINE, EMBASE, and CINAHL up to May 2012.
  • Inclusion of randomized controlled trials (RCTs) using ALE monopreparations versus placebo or standard medication.
  • Exclusion of trials involving combination therapies or ALE as part of a multi-component preparation.

Main Results:

  • Three RCTs with 262 participants were included, showing methodological quality with some limitations.
  • ALE demonstrated a statistically significant reduction in total cholesterol levels in two trials (4.2% and 18.5% decrease).
  • Mild, transient, and infrequent adverse events were reported, suggesting a favorable short-term safety profile.

Conclusions:

  • While ALE shows promise in lowering cholesterol, the current evidence is not yet conclusive.
  • Further high-quality clinical trials are necessary to substantiate the efficacy and long-term safety of ALE.
  • Limited safety data indicate ALE is well-tolerated for short-term use in managing hypercholesterolaemia.