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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
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Published on: April 7, 2017

MicroRNAs in Ewing Sarcoma.

Layne Dylla1, Colin Moore, Paul Jedlicka

  • 1Medical Scientist Training Program, University of Colorado Denver Denver, CO, USA ; Cancer Biology Graduate Program, University of Colorado Denver Denver, CO, USA ; Anschutz Medical Campus, University of Colorado Denver Denver, CO, USA.

Frontiers in Oncology
|April 2, 2013
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRs) are key gene regulators found altered in Ewing sarcoma, impacting cancer development. Targeting miRs shows therapeutic promise for this aggressive disease.

Keywords:
Ewing sarcomamicroRNAspathogenesisprognosissarcomatherapy

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Area of Science:

  • Molecular Biology
  • Oncology
  • Gene Regulation

Background:

  • MicroRNAs (miRs) are critical gene expression regulators.
  • Dysregulated miRs are implicated in cancer development and oncogenesis.
  • Ewing sarcoma is an aggressive cancer with limited treatment options.

Purpose of the Study:

  • To explore the role of microRNAs (miRs) in Ewing sarcoma.
  • To investigate miR alterations in Ewing sarcoma pathogenesis.
  • To assess the potential of miRs as biomarkers and therapeutic targets in Ewing sarcoma.

Main Methods:

  • Analysis of miR expression profiles in Ewing sarcoma.
  • Investigation of miR involvement in oncogenic fusion-dependent and independent mechanisms.
  • Evaluation of prognostic potential and therapeutic utility of miRs.

Main Results:

  • Widespread alterations in miR expression are observed in Ewing sarcoma.
  • These miR changes contribute to malignant phenotypes.
  • miRs with prognostic value have been identified.

Conclusions:

  • MicroRNA (miR) dysregulation is a significant factor in Ewing sarcoma.
  • miRs offer potential as prognostic biomarkers for Ewing sarcoma.
  • Therapeutic strategies targeting miRs may be beneficial for Ewing sarcoma treatment.