DPP4 genetic variants influence baseline prostate-specific antigen levels: the J-MICC study
Takahiro Higashibata1, Mariko Naito, Atsuyoshi Mori
1Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan. h-bata@med.nagoya-u.ac.jp
Genetic variants in DPP4 are linked to prostate-specific antigen (PSA) levels in Japanese men. These DPP4 genetic variations, particularly in older men, may influence baseline PSA, impacting prostate cancer screening accuracy.
Area of Science:
- Genetics
- Urology
- Biochemistry
Background:
- Prostate-specific antigen (PSA) testing is crucial for prostate cancer screening.
- Low positive predictive value of PSA testing results in unnecessary biopsies.
- Genetic factors may influence baseline PSA levels, necessitating further investigation.
Purpose of the Study:
- To investigate the association between Dipeptidyl peptidase-4 (DPP4) genetic variants and baseline PSA levels.
- To elucidate the role of genetic background in PSA level variations.
Main Methods:
- Cross-sectional study of 2,074 Japanese men (aged 35-69) from the J-MICC Study.
- Genotyping of three DPP4 tagging single nucleotide polymorphisms (SNPs): rs3788979, rs7608798, and rs2268889.
- Statistical analysis including trend tests and haplotype analysis.
Main Results:
- A significant association was found between higher serum PSA levels and the rs7608798 C allele (p=0.02).
- In men aged 60-69, PSA levels showed positive trends with minor alleles of rs3788979 and rs7608798 (p=0.004 and p=0.001, respectively).
- The C-A haplotype (rs7608798-rs2268889) was significantly associated with increased PSA levels (p=0.006).
Conclusions:
- DPP4 genetic variants appear to influence baseline PSA levels in Japanese men.
- This influence is particularly notable in older men (aged 60-69).
- Understanding these genetic associations could potentially improve the interpretation of PSA test results.
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