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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying DNA...
Other Stress Responses in Bacteria01:30

Other Stress Responses in Bacteria

Bacteria have global regulatory systems that control several types of stress mechanisms. These include Pho regulon and the heat shock response, which are essential systems for environmental adaptation, such as nutrient limitation and proteotoxic stress. The Pho regulon and the heat shock response exemplify bacterial resilience, enabling rapid adaptation to fluctuating environmental conditions.Pho RegulonBacteria require phosphorus for essential cellular processes, including nucleic acid...

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Related Experiment Video

Updated: May 12, 2026

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
11:31

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Published on: November 30, 2015

[Is resilience an epigenetic phenomenon?].

Bertrand Jordan1

  • 1CoReBio PACA, case 901, parc scientifique de Luminy,13288 Marseille Cedex 9, France. bertrand.jordan@univ-amu.fr

Medecine Sciences : M/S
|April 3, 2013
PubMed
Summary

Childhood trauma increases adult psychiatric risks, especially for gene variant carriers. A recent study reveals persistent epigenetic demethylation from trauma leads to heightened stress reactivity in adulthood.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Context:

  • Childhood trauma is a known risk factor for adult psychiatric disorders.
  • Genetic predispositions can exacerbate the impact of trauma.

Purpose:

  • To elucidate the molecular mechanisms linking childhood trauma, genetic factors, and adult psychiatric conditions.
  • To explain how early life stress leads to long-term changes in gene expression and stress response.

Summary:

  • Childhood trauma induces specific epigenetic modifications, namely demethylation, at critical gene loci.
  • These epigenetic changes are stable and persist into adulthood.
  • Demethylation enhances stress-induced gene expression, leading to increased reactivity and psychiatric vulnerability.

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Related Experiment Videos

Last Updated: May 12, 2026

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
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Impact:

  • Provides a mechanistic link between early life adversity and long-term mental health outcomes.
  • Highlights the role of epigenetics in mediating the effects of trauma.
  • Suggests potential targets for therapeutic interventions aimed at mitigating trauma's long-term consequences.