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Related Concept Videos

Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

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Related Experiment Video

Updated: May 12, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Community structure of non-coding RNA interaction network.

Jose C Nacher1

  • 1Department of Information Science, Faculty of Science, Toho University, Funabashi, Chiba, 274-8510, Japan. nacher@is.sci.toho-u.ac.jp

Journal of Integrative Bioinformatics
|April 3, 2013
PubMed
Summary
This summary is machine-generated.

The majority of human genes are non-coding RNA (ncRNA), yet their functions are poorly understood. This study reveals complex, modular structures in ncRNA-protein interactions, suggesting significant regulatory roles in cellular processes.

Related Experiment Videos

Last Updated: May 12, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Protein-coding genes constitute only a small fraction of the human genome (1.5%).
  • The vast majority of the genome comprises non-coding RNAs (ncRNAs), whose functions are largely unexplored.
  • Current understanding of genetic information processing may be incomplete due to the focus on protein-coding sequences.

Purpose of the Study:

  • To investigate the community structure within the functional interaction network of non-coding RNAs (ncRNAs) and protein-related biomacromolecules (PRMs).
  • To elucidate the organizational principles and potential functional implications of ncRNA interactions within the human cell.

Main Methods:

  • Utilized a two-fold approach combining modularity analysis in bipartite networks and k-clique community detection.
  • Analyzed the network of functional interactions between ncRNAs and PRMs in *Homo sapiens*.
  • Assessed community structure, modularity scores, and community size distributions.

Main Results:

  • High modularity scores and scaling-law distribution of community sizes indicated non-random network features.
  • Identified distinct communities of ncRNA molecules through k-clique subgraphs and overlaps.
  • These ncRNA communities show potential associations with specific cellular functions.

Conclusions:

  • The ncRNA-protein interaction network exhibits a complex, modular organization.
  • This modular structure suggests significant, yet underappreciated, regulatory roles for ncRNAs in cellular functions.
  • Further research into ncRNA interactions is crucial for a comprehensive understanding of genetic information processing.