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Diagnostic studies
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Related Experiment Video

Updated: May 12, 2026

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time
06:01

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time

Published on: July 26, 2024

Fiber and functional gastrointestinal disorders.

Shanti Eswaran1, Jane Muir, William D Chey

  • 1Division of Gastroenterology, University of Michigan Health System, Ann Arbor, MI 48109-5362, USA.

The American Journal of Gastroenterology
|April 3, 2013
PubMed
Summary

Evidence for fiber in functional bowel disease is limited. Soluble fiber supplements like psyllium are best supported, but can worsen symptoms such as bloating and diarrhea.

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Published on: September 11, 2012

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Last Updated: May 12, 2026

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time
06:01

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Published on: July 26, 2024

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation
09:44

Functional Assessment of Intestinal Motility and Gut Wall Inflammation in Rodents: Analyses in a Standardized Model of Intestinal Manipulation

Published on: September 11, 2012

Area of Science:

  • Gastroenterology
  • Dietary Science

Background:

  • Limited evidence exists for fiber's efficacy in functional bowel disease.
  • Fiber intake is often advised for gastrointestinal health.
  • Understanding fiber types and fermentation is crucial.

Purpose of the Study:

  • To review fiber types and their fermentation characteristics.
  • To guide the selection of appropriate fiber strategies for functional bowel disease patients.
  • To highlight the current evidence supporting fiber use.

Main Methods:

  • Literature review of fiber types and their properties.
  • Analysis of fermentation characteristics of different fibers.
  • Evaluation of clinical evidence for fiber in functional bowel disease.

Main Results:

  • Fiber fermentation produces short-chain fatty acids and gas, impacting gut function.
  • Soluble fiber supplements, specifically ispaghula/psyllium, have the strongest evidence base.
  • Fiber supplementation can paradoxically worsen symptoms like bloating, gas, constipation, and diarrhea.

Conclusions:

  • Careful consideration of fiber type and fermentation is necessary for functional bowel disease management.
  • While psyllium shows promise, its use requires judicious application due to potential side effects.
  • Further research is needed to clarify optimal fiber strategies for these conditions.