Related Experiment Video

Updated: May 12, 2026

Purification of Endogenous Drosophila Transient Receptor Potential Channels
08:39

Purification of Endogenous Drosophila Transient Receptor Potential Channels

Published on: December 28, 2021

[Function and role of transient receptor potential channels]

Motohiro Nishida1, Masaaki Sumita, Naoyuki Kitajima

  • 1Department of Drug Discovery and Evolution, Kyushu University, Japan.

Clinical Calcium
|April 3, 2013
PubMed

Insights

Transient receptor potential (TRP) channels play a role in heart failure by contributing to cardiac remodeling. New TRPC channel inhibitors offer potential therapeutic strategies for treating heart failure.

Area of Science:

  • Molecular biology
  • Cardiovascular physiology
  • Ion channel function

Context:

  • Transient receptor potential (TRP) proteins form Ca(2+)-permeable cation channels activated by various stimuli, excluding membrane depolarization.
  • TRP channels are increasingly recognized for their pathophysiological involvement in heart failure.
  • Canonical TRP (TRPC) channels are specifically implicated in neurohumoral factor-induced cardiac structural remodeling.

Purpose:

  • To elucidate the role of TRPC channels in the molecular mechanisms underlying heart failure.
  • To highlight the dual function of TRPC proteins as channel components and signaling scaffolds.
  • To review the recent development of selective TRPC channel inhibitors for potential therapeutic applications.

Summary:

  • TRPC channels contribute to cardiac remodeling in heart failure by acting as cation channels and protein scaffolds that amplify receptor signaling.
  • These channels are activated by neurohumoral factors, making them key players in the progression of heart failure.
  • The identification of selective TRPC inhibitors presents a promising avenue for drug discovery in heart failure treatment.

Impact:

  • Understanding TRPC channel function provides insights into the molecular basis of heart failure.
  • Targeting TRPC channels could lead to novel therapeutic interventions for heart failure.
  • This research highlights the potential of pharmacological modulation of ion channels for cardiovascular disease treatment.

More Related Videos

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV412:09

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

Published on: December 31, 2013

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

Related Concept Videos

Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Ion Channels01:19

Ion Channels

The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow specific...
The Role of Ion Channels in Neuronal Computation01:19

The Role of Ion Channels in Neuronal Computation

A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...