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Newer antipsychotics and upcoming molecules for schizophrenia
Melvin George1, Radhika Amrutheshwar, Ravi Philip Rajkumar
1Department of Cardiology, SRM Medical College Hospital & Research Centre, Chennai, India. melvingeorge2003@gmail.com
European Journal of Clinical Pharmacology
|April 3, 2013
Summary
New antipsychotics like iloperidone, asenapine, lurasidone, and blonanserin offer improved schizophrenia treatment. Future research targets novel pathways for enhanced efficacy and tolerability.
Area of Science:
- Psychopharmacology
- Neuroscience
Background:
- Schizophrenia management has advanced with new antipsychotics.
- Current treatments show limited efficacy for negative/cognitive symptoms and have adverse effects.
- There is a need for novel antipsychotic agents targeting unexplored pathways.
Purpose of the Study:
- To review recently approved antipsychotics: iloperidone, asenapine, lurasidone, and blonanserin.
- To discuss their advantages, limitations, and role in pharmacotherapy.
- To highlight emerging therapeutic targets for schizophrenia.
Main Methods:
- Literature review of recently approved antipsychotics.
- Analysis of clinical data regarding efficacy and safety.
- Exploration of novel molecular targets in psychiatric research.
Main Results:
- Iloperidone, asenapine, lurasidone, and blonanserin represent recent advancements in antipsychotic pharmacotherapy.
- Emerging strategies focus on modulating glutamatergic, GABAergic, and cholinergic systems.
- These novel targets hold promise for addressing unmet needs in schizophrenia treatment.
Conclusions:
- Despite recent approvals, a need for more effective antipsychotics persists.
- Exploration of diverse molecular targets could lead to revolutionary psychiatric treatments.
- Future antipsychotics may offer improved efficacy, tolerability, and patient outcomes.
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