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Updated: May 12, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Cytochrome P450 drug interactions with statin therapy
Ivanna Xin Wei Goh1, Choon How How, Subramaniam Tavintharan
1National Healthcare Group Polyclinics, Woodlands Polyclinic, 10 Woodlands Street 31, Singapore. ivanna.goh@mohh.com.sg
Abstract:
Statins are commonly used in the treatment of hyperlipidaemia. Although the benefits of statins are well-documented, they have the potential to cause myopathy and rhabdomyolysis due to the complex interactions of drugs, comorbidities and genetics. The cytochrome P450 family consists of major enzymes involved in drug metabolism and bioactivation. This article aims to highlight drug interactions involving statins, as well as provide updated recommendations and approaches regarding the safe and appropriate use of statins in the primary care setting.
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