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A Catheter-Related Candida albicans Infection Model in Mouse
Published on: March 22, 2024
[Candida sp endocarditis. Experience in a third-level hospital and review of the literature]
Alicia Hernández-Torres1, Elisa García-Vázquez, Alicia Laso-Ortiz
1Servicio MI Infecciosas Hospital Universitario Virgen de la Arrixaca, Carretera Madrid- Cartagena, S/N. 30120. El Palmar, Murcia, Spain. maliht_1@hotmail.com
Abstract:
Despite the relative high frequency of Candida bloodstream infection, Candida endocarditis is a rare entity. We report five cases of Candida endocarditis admitted to our hospital in the period between 2005 and 2011. Two cases were caused by C. albicans, two cases were caused by C. parapsilosis and in the last one, we didn't identify the species of Candida. All but one had clear risk factors for candidemia. Treatment consisted of amphotericin B with / without flucytosine in four patients, and they all underwent surgery for valve replacement and / or removal of intravascular devices. Overall mortality was 60% (40% of mortality was directly related to endocarditis). All patients who survived were given suppressive therapy with fluconazole for a minimum of two years.After stopping fluconazole there was a case of recurrence.
Insights
Candida endocarditis is rare but serious. Treatment involves antifungal drugs and surgery, with a high mortality rate and risk of recurrence, even after long-term fluconazole therapy.
Area of Science:
- Infectious Diseases
- Cardiology
- Mycology
Background:
- Candida bloodstream infection (CSI) is relatively common.
- Candida endocarditis (CE) is a rare but severe complication of CSI.
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