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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Platelet physiology

Matthew D Linden1

  • 1Centre for Microscopy, Characterisation and Analysis, University of Western Australia, Crawley, WA, Australia.

Methods in Molecular Biology (Clifton, N.J.)
|April 3, 2013
PubMed

Platelets are cell fragments which circulate in blood. They are of pivotal importance in blood clot formation, affecting thrombosis and haemostasis. By rapidly altering the activation and expression of surface receptors, platelets are able to quickly undergo structural and phenotypic changes in response to stimulation, such as collagen exposure on injured vascular endothelium. This response to stimulation allows platelets to become adhesive, aggregate to form a thrombus, and release a variety of mediators affecting coagulation, inflammation, and chemotaxis at the site of injury. Therefore, in addition to their critical role in thrombosis and haemostasis, platelets also play a role in immunity, inflammation, wound healing, haematologic malignancies, and metabolic disorders. The role of platelets in disease, particularly in atherothrombosis, is increasingly the focus of current research and antiplatelet therapy plays a significant role in the prevention and treatment of atherothrombotic and inflammatory diseases.

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