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Assessment of Plasma Coagulation on Liver Tissue in a Large Animal Model In Vivo
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Methods of coagulation
1Department of Haematology, Royal Children's Hospital, Melbourne, Australia.
Methods in Molecular Biology (Clifton, N.J.)
|April 3, 2013
Summary
Investigating normal blood coagulation in the lab requires diverse methods like clot-based tests and chromogenic assays. Ensuring reliable results depends on adhering to international standards, quality management, and assurance programs.
Area of Science:
- Clinical pathology
- Hematology
- Biochemistry
Background:
- Haemostasis, the process of normal blood coagulation, is critical for hemostasis.
- Laboratory investigations aim to accurately replicate in vivo coagulation processes.
Purpose of the Study:
- To outline methodologies for laboratory investigation of haemostasis.
- To emphasize the importance of quality assurance in coagulation testing.
Main Methods:
- Utilizing clot-based coagulation tests.
- Employing chromogenic assays.
- Conducting immunological tests and aggregation studies.
- Leveraging automated laboratory instrumentation.
Main Results:
- A variety of methods are available for haemostasis investigation.
- Automated platforms enhance the efficiency of coagulation testing.
- Adherence to international standards is crucial for result accuracy.
Conclusions:
- Reliable haemostasis testing necessitates established methodologies and adherence to international guidelines.
- Implementing a robust quality management plan, including internal quality control and external quality assurance, is essential for laboratory accreditation and accurate patient results.
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