Related Experiment Video
Updated: Oct 7, 2025
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Research Priorities for Plasma and Platelet Transfusion Strategies in Critically Ill Children: From the Transfusion
Marianne E Nellis1, Kenneth E Remy2, Jacques Lacroix3
1Division of Pediatric Critical Care Medicine, Department of Pediatrics, NY Presbyterian Hospital - Weill Cornell Medicine, New York, NY.
Insights
High-priority research is needed for plasma and platelet transfusions in critically ill children. Studies on efficacy, dosing, and timing will guide evidence-based transfusion recommendations.
Area of Science:
- Pediatric critical care medicine
- Transfusion medicine
- Hematology
Background:
- Critically ill children often require plasma and platelet transfusions.
- Current transfusion practices lack robust evidence-based guidelines.
- The Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding (TAXI-CAB) aimed to address this gap.
Purpose of the Study:
- To establish high-priority research initiatives for plasma and platelet transfusions in critically ill children.
- To identify key areas for future research to improve transfusion management.
- To inform the development of evidence-based transfusion guidelines.
Main Methods:
- Systematic review and consensus conference involving international multidisciplinary experts.
- Modified Research and Development/University of California, Los Angeles methodology used to develop research priorities.
- Expert panel identified priorities across various pediatric subpopulations and transfusion-related aspects.
Main Results:
- Four overarching themes and 14 specific research priorities were developed.
- Priorities focused on subpopulations including trauma, traumatic brain injury, oncologic diagnoses, sepsis, and more.
- Research areas include transfusion efficacy, harm, dosing, timing, component selection, and guiding tests.
Conclusions:
- Further research is essential to determine the efficacy and safety of plasma and platelet transfusions in critically ill children.
- Studies addressing dosing, timing, and specific outcomes are crucial.
- Evidence generated will support the creation of evidence-based transfusion recommendations for pediatric critical care.
Objectives:
To present a list of high-priority research initiatives for the study of plasma and platelet transfusions in critically ill children from the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding.
Design:
Systematic review and consensus conference of international, multidisciplinary experts in platelet and plasma transfusion management of critically ill children.
Setting:
Not applicable.
Patients:
Critically ill pediatric patients at risk of bleeding and receiving plasma and/or platelet transfusions.
Interventions:
None.
Measurements And Main Results:
A panel of 13 experts developed research priorities for the study of plasma and platelet transfusions in critically ill children which were reviewed and ratified by the 29 Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding experts. The specific priorities focused on the following subpopulations: severe trauma, traumatic brain injury, intracranial hemorrhage, cardiopulmonary bypass surgery, extracorporeal membrane oxygenation, oncologic diagnosis or stem cell transplantation, acute liver failure and/or liver transplantation, noncardiac surgery, invasive procedures outside of the operating room, and sepsis and/or disseminated intravascular coagulation. In addition, tests to guide plasma and platelet transfusion, as well as component selection and processing, were addressed. We developed four general overarching themes and 14 specific research priorities using modified Research and Development/University of California, Los Angeles methodology.
Conclusions:
Studies are needed to focus on the efficacy/harm, dosing, timing, and outcomes of critically ill children who receive plasma and/or platelet transfusions. The completion of these studies will facilitate the development of evidence-based recommendations.
More Related Videos
Related Concept Videos
01:24Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
02:45Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
01:22Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
01:05Introduction to Hemostasis
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
01:15Blood Transfusion
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
01:30Venous Thrombosis IV: Nursing Management