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Flow Cytometry

Flow Cytometry

The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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Related Experiment Video

Updated: May 12, 2026

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

Platelet flow cytometry.

Matthew D Linden¹

¹Centre for Microscopy, Characterisation and Analysis, University of Western Australia, Crawley, WA, Australia.

Methods in Molecular Biology (Clifton, N.J.)

|April 3, 2013

Summary

This summary is machine-generated.

Flow cytometry offers detailed platelet analysis, assessing physical and antigenic properties. This aids in diagnosing platelet disorders and monitoring antiplatelet therapy effectiveness.

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Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets

Published on: November 22, 2024

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Last Updated: May 12, 2026

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets

Published on: November 22, 2024

Area of Science:

Hematology
Immunology
Biotechnology

Background:

Flow cytometry is a key technique for analyzing cellular characteristics.
Platelets play crucial roles in hemostasis, thrombosis, and inflammation.
Understanding platelet phenotype is vital for diagnosing and managing various diseases.

Purpose of the Study:

To highlight the utility of flow cytometry in platelet research.
To demonstrate how flow cytometry quantifies platelet physical and antigenic properties.
To showcase its application in clinical diagnostics and therapeutic monitoring.

Main Methods:

Utilizing flow cytometry to analyze platelet surface receptors and granule components.
Quantifying platelet aggregation and interactions with leukocytes and coagulation factors.
Assessing physical properties like size and granularity.

Main Results:

Flow cytometry provides comprehensive phenotypic data on platelets.
Quantitative assessment of surface markers, bound ligands, and granule release.
Detection of platelet interactions with other blood cells and plasma systems.

Conclusions:

Flow cytometry is a versatile tool for detailed platelet phenotyping.
Quantitative analysis aids in diagnosing platelet disorders and related diseases.
It is valuable for monitoring antiplatelet drug safety and efficacy.