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Updated: May 12, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis and antimicrobial activity of novel benzo[f]coumarin compounds
Remon M Zaki1, Yasser A Elossaily, Adel M Kamal El-Dean
1Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt. remonch2003@yahoo.com
Abstract:
The acetyl benzo[f]coumarin condensed with phenyl hydrazine to afford the corresponding phenyl hydrazone which cyclized into the pyrazolyl benzocoumarin under Vilsmeier reaction conditions. The pyrazolylaIdehyde was used as starting material for synthesis of other heterocyclic compounds containing pyrazolylbenzocoumarin moiety. The ethyl benzo[f]coumarin carboxylate were subjected to react with other reagents to synthesize thiazolidinyl and oxadiazolyl derivatives attached to benzocoumarin system. Some of novel synthesized compounds showed highly antibacterial and antifungal activities.
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