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Related Experiment Video

Updated: May 12, 2026

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

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Published on: January 22, 2019

Sirtuin-1 and HIV-1: an overview.

Marilia Rita Pinzone¹, Bruno Cacopardo, Fabrizio Condorelli

¹Department of Clinical and Molecular Biomedicine, Division of Infectious Diseases, University of Catania, Via Palermo 636, Zip 95125, ARNAS Garibaldi Nesima, Catania, Italy.

Current Drug Targets

|April 4, 2013

Summary

Sirtuin-1 (SIRT1) influences Human Immunodeficiency Virus (HIV)-1 transcription by regulating the viral Tat protein. Suppressing SIRT1 activity by Tat may drive chronic immune activation in HIV-infected individuals.

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Last Updated: May 12, 2026

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Published on: February 27, 2016

Peptide-based Identification of Functional Motifs and their Binding Partners

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

Area of Science:

Biochemistry
Molecular Biology
Immunology

Background:

Sirtuins are NAD+-dependent deacetylases regulating key cellular processes.
Sirtuin-1 (SIRT1) plays a role in modulating Human Immunodeficiency Virus (HIV)-1 transcription.
HIV-1 Tat protein is deacetylated by SIRT1, a crucial step for viral transcription.

Purpose of the Study:

To review the biological functions of sirtuins.
To delineate the interplay between SIRT1 and HIV-1.
To discuss SIRT1 as a potential therapeutic target for HIV-1 replication.

Main Methods:

Literature review of sirtuin and HIV-1 interactions.
Analysis of SIRT1's role in HIV-1 Tat deacetylation.
Investigation of Tat-induced suppression of SIRT1 activity.

Main Results:

SIRT1 deacetylates HIV-1 Tat, enabling viral transcription.
HIV-1 Tat suppresses SIRT1 activity by interacting with its deacetylase domain.
Tat-induced inhibition of SIRT1 leads to nuclear factor-κB (NF-κB) pathway hyperactivation.

Conclusions:

The interaction between SIRT1 and HIV-1 Tat is critical for viral replication.
Tat-mediated suppression of SIRT1 contributes to chronic immune activation in HIV infection.
SIRT1 represents a promising pharmacological target for controlling HIV-1 replication.