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Related Experiment Video

Updated: May 12, 2026

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
07:51

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

Factors affecting corneoscleral topography.

Lee A Hall1, Chris Hunt, Graeme Young

  • 1Visioncare Research Ltd., Farnham, United Kingdom. l.hall@visioncare.co.uk

Investigative Ophthalmology & Visual Science
|April 4, 2013
PubMed
Summary

Age is the primary factor influencing the corneoscleral profile (CSP), impacting ocular topography. Understanding these age-related changes is crucial for contact lens fitting and surgical planning.

Keywords:
OCTcorneal topographycorneoscleral profile

Related Experiment Videos

Last Updated: May 12, 2026

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
07:51

Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts

Published on: October 21, 2022

Area of Science:

  • Ophthalmology and optometry
  • Biomedical engineering
  • Anatomical sciences

Background:

  • The corneoscleral profile (CSP) is a key anatomical feature influencing ophthalmic device fitting and surgical outcomes.
  • Anterior segment optical coherence tomography (AS-OCT) and videokeratoscopy provide detailed measurements of the anterior segment.
  • Understanding factors affecting CSP is essential for personalized ophthalmic care.

Purpose of the Study:

  • To evaluate the factors affecting the corneoscleral profile (CSP) using AS-OCT and videokeratoscopy.
  • To identify demographic and refractive variables associated with variations in CSP.

Main Methods:

  • AS-OCT and corneal topography data were collected from 204 subjects (age 18-65).
  • Measurements included corneal diameter, sagittal height, iris diameter, corneoscleral junction angle, and scleral radius.
  • Associations were analyzed between CSP variables and age, height, ethnicity, sex, and refractive error.

Main Results:

  • Age was the most significant factor influencing CSP, accounting for 36% of the variance in topography variables.
  • Significant correlations were found between age and multiple ocular topography variables (P < 0.0001).
  • Ocular topography also varied significantly with height, sex, and ethnicity (P < 0.05).

Conclusions:

  • Age is the primary determinant of the corneoscleral profile (CSP).
  • These findings are critical for optimizing contact lens design, intraocular lens (IOL) selection, and surgical procedures.
  • Ocular topography exhibits variability based on height, sex, ethnicity, and refractive error, necessitating individualized approaches.