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Efficient and Site-specific Antibody Labeling by Strain-promoted Azide-alkyne Cycloaddition
Published on: December 23, 2016
Interfacial strain-promoted alkyne-azide cycloaddition (I-SPAAC) for the synthesis of nanomaterial hybrids
Pierangelo Gobbo1, Samantha Novoa, Mark C Biesinger
1Department of Chemistry and Centre for Advanced Materials and Biomaterials, The University of Western Ontario, 1151 Richmond St., London, ON, Canada N6A 5B7.
Chemical Communications (Cambridge, England)
|April 4, 2013
Abstract:
An interfacial strain promoted azide-alkyne cycloaddition (I-SPACC) is introduced as a method to prepare robust nanomaterial hybrids. This is demonstrated with a reaction between a novel dibenzocyclooctyne-modified single walled carbon nanotubes (DBCO-SWCNT) and a versatile water-soluble azide modified gold nanoparticle (N3-EG4-AuNP).
