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Microscopic colitis in children with chronic diarrhea.
Prashant Singh1, Prasenjit Das, A K Jain
1Department of Pediatrics, Center for Diarrheal Diseases and Nutrition Research, Indian Council of Medical Research, New Delhi, India.
Journal of Pediatric Gastroenterology and Nutrition
|April 4, 2013
Summary
Microscopic colitis (MC) was identified in children experiencing chronic diarrhea. This condition, characterized by specific mucosal biopsy changes, warrants further investigation into its prevalence in pediatric populations.
Area of Science:
- Pediatric Gastroenterology
- Gastrointestinal Pathology
Background:
- Chronic diarrhea in children can be challenging to diagnose.
- Microscopic colitis (MC) is an underrecognized cause of chronic diarrhea.
Purpose of the Study:
- To investigate the prevalence and characteristics of microscopic colitis in children with chronic diarrhea.
- To analyze mucosal biopsy changes associated with MC in pediatric patients.
Main Methods:
- 100 children (3-12 years) with chronic nonbloody diarrhea were screened.
- Colonoscopies and colonic biopsies were performed to identify lymphocytic colitis or collagenous colitis.
- Biopsies were compared between children with MC, chronic diarrhea without MC, and those with rectal bleeding.
Main Results:
- Microscopic colitis was diagnosed in 5 of 26 children with chronic diarrhea (3 lymphocytic colitis, 2 collagenous colitis).
- Children with MC showed significantly higher polymorphonuclear infiltration compared to control groups.
- Increased intraepithelial lymphocytes and basement membrane thickening were observed in MC patients.
Conclusions:
- Microscopic colitis is a relevant diagnosis in children presenting with chronic nonbloody diarrhea.
- Further multicenter studies are needed to establish the prevalence of pediatric microscopic colitis.
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