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Updated: May 12, 2026
15:07
VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
Published on: December 28, 2015
Molecular lesions in B-cell lymphoproliferative disorders: recent contributions from studies utilizing
Piers A Blombery1, Michael Dickinson, David A Westerman
1Peter MacCallum Cancer Centre, Division of Cancer Medicine , East Melbourne, Victoria , Australia.
Leukemia & Lymphoma
|April 5, 2013
Summary
Next-generation sequencing reveals genetic mutations in B-cell cancers. These findings illuminate oncogenic pathways and identify new therapeutic targets for blood cancers.
Area of Science:
- Genomics
- Hematology
- Oncology
Background:
- Next-generation sequencing (NGS) has revolutionized the study of hematological malignancies.
- Comprehensive genomic profiling has been applied to various B-cell lymphoproliferative disorders.
Purpose of the Study:
- To review molecular lesions discovered in B-cell lymphoproliferative disorders using high-throughput sequencing.
- To summarize pathway aberrations implicated in oncogenesis.
Main Methods:
- High-throughput sequencing techniques.
- Genomic data analysis of B-cell lymphoproliferative disorders.
Main Results:
- Identification of genetic lesions in chronic lymphocytic leukemia, diffuse large B-cell lymphoma, and other B-cell malignancies.
- Elucidation of dysregulated pathways, including nuclear factor-κB (NF-κB) and mRNA processing.
- Discovery of disease-defining mutations and novel therapeutic targets.
Conclusions:
- NGS has significantly advanced our understanding of B-cell lymphoproliferative disorders.
- Identified molecular lesions and pathway aberrations offer promising therapeutic avenues.
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