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Oral focal acantholytic dyskeratosis
1Department of Oral Pathology, Indiana University School of Dentistry, Indianapolis.
The Journal of Dermatologic Surgery and Oncology
|June 1, 1990
Summary
Focal acantholytic dyskeratosis (FAD) is a rare oral lesion. This study presents 15 new cases, finding that some FAD lesions appear as leukoplakia, suggesting a potential addition to FAD classification.
Area of Science:
- Oral pathology
- Dermatopathology
- Histopathology
Background:
- Focal acantholytic dyskeratosis (FAD) is an uncommon condition affecting the oral mucosa.
- Literature review indicates only 22 previously reported cases of solitary oral FAD.
Purpose of the Study:
- To present an additional series of solitary oral FAD cases.
- To investigate the clinical presentation of oral FAD, particularly its association with leukoplakia.
- To evaluate potential modifications to the current classification of solitary FAD.
Main Methods:
- Retrospective case series analysis.
- Clinical and histopathological review of 15 cases diagnosed with solitary oral FAD.
- Comparison of clinical presentation with histopathological findings.
Main Results:
- Fifteen additional cases of solitary oral FAD were identified and analyzed.
- Four of the presented cases exhibited clinical features consistent with leukoplakia.
- Histopathological examination confirmed FAD in all 15 cases.
Conclusions:
- Solitary oral focal acantholytic dyskeratosis is a distinct clinicopathological entity.
- The occurrence of FAD in association with leukoplakia warrants consideration.
- Leukoplakia-associated FAD may represent a variant or an addition to the current classification of solitary FAD.