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Updated: May 12, 2026
Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
Published on: August 14, 2019
Clinical experience of modified diffusion-weighted imaging protocol for lesion detection in transient global amnesia:
Jungeun Kim1, Yooseok Kwon, Youngsoon Yang
1Department of Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Background And Purpose:
The detection rate of typical transient global amnesia (TGA) lesions on diffusion-weighted imaging (DWI) can be improved, up to 85% with optimal DWI parameters and imaging time. There is limited evidence that these findings are similar to those observed in large-scale consecutive patients with TGA in clinical practice.
Methods:
Patients with clinically diagnosed TGA underwent magnetic resonance imaging studies, consecutively, with three sets of DWI parameters (standard clinical DWI protocols, the TGA DWI protocol I and the TGA DWI protocol II) in which the resolution, slice thickness, and the time interval between symptom onset of DWI were varied over an 8-year period.
Results:
TGA lesion detection rates were up to 88% with a modified TGA DWI protocol. The lesion detection rate was the highest using TGA DWI protocol I, with b = 3,000 s/mm(2), a slice thickness of 3 mm, and performed on the third day after symptom onset, and TGA DWI protocol II, with b = 2,000 s/mm(2) and a slice thickness of 2 mm.
Conclusions:
A modified TGA DWI protocols for detecting TGA lesions are useful in large-scale clinical practice for confirming the diagnosis of TGA patients with clinical findings.
