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Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
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Synthesis, tautomeric structures, and antitumor activity of new perimidines

Thoraya A Farghaly1, Huda K Mahmoud

  • 1Faculty of Science, Department of Chemistry, University of Cairo, Giza, Egypt. thoraya-f@hotmail.com

Archiv Der Pharmazie
|April 5, 2013
PubMed

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Basicity of Heterocyclic Aromatic Amines

Heterocyclic amines, where the N atom is a part of an alicyclic system, are similar in basicity to alkylamines. Interestingly, the heterocyclic amine having a nitrogen atom as part of an aromatic ring has much less basicity than its corresponding alicyclic counterpart. For this reason, as presented in Figure 1, piperidine (pKb = 2.8) is significantly more basic than pyridine (pKb = 8.8).
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