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Homer proteins in Ca²⁺ entry

Isaac Jardin1, José J López, Alejandro Berna-Erro

  • 1Department of Physiology (Cellular Physiology Research Group), University of Extremadura, Cáceres, Spain.

IUBMB Life
|April 5, 2013
PubMed

Insights

Homer 1 proteins are key regulators of intracellular calcium (Ca2+) handling. This review explores their critical role in maintaining cellular calcium homeostasis by interacting with various Ca2+-handling proteins.

Area of Science:

  • Molecular Biology
  • Cellular Physiology
  • Biochemistry

Background:

  • The Homer family comprises three adaptor proteins (Homer1, Homer2, Homer3) with diverse isoforms.
  • Homer1 proteins possess specific structural domains: EVH1, coiled coil, and leucine zippers.
  • Homer proteins are known to interact with numerous Ca2+-handling proteins.

Purpose of the Study:

  • To review the association of Homer 1 proteins with Ca2+-handling proteins.
  • To elucidate the role of Homer 1 proteins in intracellular Ca2+ homeostasis.

Main Methods:

  • Literature review of studies on Homer 1 proteins and Ca2+ handling.
  • Analysis of protein-protein interactions.
  • Examination of cellular Ca2+ signaling pathways.

Main Results:

  • Homer 1 proteins form complexes with transient receptor potential channels.
  • They interact with glutamate receptors and shank scaffolding proteins.
  • Homer 1 proteins influence endoplasmic reticulum Ca2+ release channels.

Conclusions:

  • Homer 1 proteins are crucial for regulating Ca2+ flux across cellular compartments.
  • Their interactions are vital for maintaining intracellular Ca2+ balance.
  • Dysregulation of Homer 1 function may impact cellular signaling and homeostasis.

Keywords:
HomerIP3RPMCATRP channels

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