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Updated: May 12, 2026
14:57
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Association between p53 Pro72Arg polymorphism and prostate cancer risk: a meta-analysis
Lifeng Zhang1, Ning Shao, Qianqian Yu
1Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China;
Journal of Biomedical Research
|April 5, 2013
Summary
The p53 codon Pro72Arg polymorphism shows a weak association with prostate cancer risk. This meta-analysis of 10 studies found no significant overall risk, but a modest decrease in risk was observed in population-based controls.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- The tumor suppressor gene p53 is implicated in various human cancers, including prostate cancer.
- The p53 codon72 polymorphism (Pro72Arg) association with prostate cancer risk is widely studied but yields inconsistent results.
Purpose of the Study:
- To conduct an updated meta-analysis to precisely estimate the relationship between p53 codon72 polymorphism and prostate cancer risk.
- To synthesize findings from multiple case-control studies to clarify the genetic association.
Main Methods:
- Systematic literature search of PubMed up to July 2010 without language restriction.
- Inclusion of 10 case-control studies comprising 1,196 cases and 1,704 controls.
- Meta-analysis using risk ratios (RR) and 95% confidence intervals (CIs) to assess association strength, with stratified analyses by ethnicity and control type.
Main Results:
- Overall, no significant association was found between p53 codon polymorphism and total prostate cancer risk (Pro/Pro vs Arg/Arg: RR=1.12; Pro/Pro+Pro/Arg vs Arg/Arg: RR=1.05).
- Stratified analysis by ethnicity did not reveal significant associations.
- A modest decreased association was observed in the subgroup analysis of population-based controls under a recessive genetic model (RR=0.31).
Conclusions:
- The p53 codon Pro72Arg polymorphism demonstrates a weak association with prostate cancer risk.
- Further research may be needed to elucidate the specific role of this polymorphism, particularly in certain subgroups or under specific genetic models.
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