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Mesenteric paraganglioma: Report of a case
Takeshi Fujita1, Kinji Kamiya, Yoshiaki Takahashi
1Takeshi Fujita, Kinji Kamiya, Yoshiaki Takahashi, Shinichiro Miyazaki, Ichirota Iino, Hirotoshi Kikuchi, Yoshihiro Hiramatsu, Manabu Ohta, Hiroyuki Konno, Second Department of Surgery, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan.
World Journal of Gastrointestinal Surgery
|April 5, 2013
Summary
This case report details an extremely rare mesenteric paraganglioma in the terminal ileum. Surgical removal was successful, with the patient showing no recurrence a year later, highlighting effective treatment for this rare tumor.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Pathology
Background:
- Paragangliomas are rare neuroendocrine tumors originating from extra-adrenal chromaffin cells.
- Mesenteric paragangliomas are exceptionally rare, with limited documented cases.
- Extra-adrenal paragangliomas typically arise near the aorta, often associated with the organ of Zuckerkandl.
Purpose of the Study:
- To report a rare case of paraganglioma originating in the mesentery of the terminal ileum.
- To discuss the clinical presentation, diagnostic features, and management of mesenteric paraganglioma.
- To contribute to the limited literature on this rare tumor entity.
Main Methods:
- A case study of a 78-year-old female patient presenting with abdominal pain.
- Diagnostic imaging using abdominal computed tomography (CT) to identify the mass.
- Surgical excision of the mesenteric tumor via laparoscopy.
- Histopathological and immunohistochemical analysis of the resected tumor tissue.
Main Results:
- A 3 cm well-circumscribed, encapsulated mesenteric tumor was successfully laparoscopically excised.
- Histology revealed a characteristic nested Zellballen pattern.
- Immunohistochemistry confirmed tumor cells positive for chromogranin, synaptophysin, CD56, and vimentin.
- The patient experienced an unremarkable postoperative course and remained recurrence-free at 1-year follow-up.
Conclusions:
- Mesenteric paraganglioma is an extremely rare diagnosis, posing diagnostic and surgical challenges.
- Laparoscopic excision is a viable and effective treatment option for mesenteric paraganglioma.
- Complete surgical resection appears to lead to favorable long-term outcomes in these rare cases.