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A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
A novel pressure difference-induced perforation aortic stent-grafts system: an experimental study
Guo-Yu Deng1, Jian Zhou, Qing-Sheng Lu
1Department of Vascular Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Chinese Medical Journal
|April 6, 2013
Summary
A novel stent-graft system allows in situ fenestration by utilizing the pressure difference between the left subclavian artery and the aortic arch, reducing the need for extensive preoperative imaging.
Area of Science:
- Biomedical Engineering
- Vascular Surgery
- Medical Devices
Background:
- Customized stent-graft modifications for side branch preservation often require extensive preoperative assessment, posing challenges in emergency settings.
- Existing methods for preserving side branches during endovascular procedures can be complex and resource-intensive.
- The need for adaptable stent-graft solutions that minimize reliance on detailed preoperative imaging is critical.
Purpose of the Study:
- To develop and evaluate a novel stent-graft system capable of in situ fenestration.
- To assess the feasibility of a stent-graft that creates fenestrations based on pressure differentials.
- To reduce the dependency on extensive preoperative imaging for endovascular stent-graft modifications.
Main Methods:
- Measured pressure differences (PD) between the left subclavian artery (LSA) and the aortic arch in 12 experimental pigs.
- Developed a novel stent graft using multi-dimensional and multiple textiles forming technology.
- Evaluated the stent-graft's feasibility in a mock circulation system based on pig PD measurements.
Main Results:
- A significant pressure difference (42.78 ± 5.17 mmHg) was observed between the aortic arch and the LSA after the LSA was covered in pigs (P < 0.001).
- The novel stent-graft demonstrated in situ fenestration, with contrast media oozing into the LSA when the PD reached the measured magnitude.
- Fenestration occurred due to the sliding and deformation of the stent-graft's yarns, triggered by the pressure differential.
Conclusions:
- The proposed pressure difference-induced perforation aortic stent-graft system is feasible.
- The pressure difference between the left subclavian artery and the aortic arch is sufficient to enable in situ fenestration.
- The novel stent-graft, constructed with advanced textile technology, successfully achieved fenestration based on pressure differentials.
