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Nuclear actin network assembly by formins regulates the SRF coactivator MAL

Christian Baarlink1, Haicui Wang, Robert Grosse

  • 1Institute of Pharmacology, Biochemical-Pharmacological Center, University of Marburg, Germany.

Science (New York, N.Y.)
|April 6, 2013
PubMed
Summary

Formins build actin filaments in the nucleus, activating serum response factor (SRF) transcriptional activity. This nuclear actin assembly, driven by formins like mDia, is key to the cell's serum response.

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