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Related Concept Videos

Adherens Junctions01:24

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...
Desmosomes01:05

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...

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Related Experiment Video

Updated: May 12, 2026

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

Dysferlin regulates cell adhesion in human monocytes.

Antoine de Morrée1, Bàrbara Flix2, Ivana Bagaric1

  • 1Department of Human Genetics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

The Journal of Biological Chemistry
|April 6, 2013
PubMed
Summary

Dysferlin protein is crucial for immune cell function in muscular dystrophies. Its absence in monocytes impairs cell adhesion and motility, potentially worsening disease progression.

Keywords:
Cell AdhesionIntegrinMonocytesMuscular DystrophySkeletal Muscle

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Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
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Published on: June 29, 2016

Area of Science:

  • Cell Biology
  • Immunology
  • Muscle Diseases

Background:

  • Dysferlin mutations cause dysferlinopathies, a group of muscular dystrophies.
  • Dysferlin is vital for skeletal muscle membrane repair and is also found in monocytes.
  • Dysferlinopathy patients exhibit significant immune cell infiltration in muscles.

Purpose of the Study:

  • To investigate the role of dysferlin in monocyte function and its contribution to dysferlinopathies.
  • To elucidate the molecular mechanisms underlying dysferlin deregulation in inflammatory cells.

Main Methods:

  • Studied dysferlin expression during human monocyte differentiation using THP1 cell models.
  • Analyzed fibronectin and integrin expression in monocytes from dysferlinopathy patients.
  • Investigated the interaction of dysferlin with integrins and its effect on cell adhesion and motility.

Main Results:

  • Dysferlin expression increases with monocyte differentiation.
  • Dysferlinopathy monocytes show altered fibronectin and integrin expression.
  • Dysferlin depletion impairs monocyte adhesion by disrupting the dysferlin-integrin complex.
  • Patient-derived macrophages exhibit changes in adhesion and motility.

Conclusions:

  • Dysferlin plays a significant role in regulating monocyte and macrophage adhesion and motility.
  • Dysferlin's function in inflammatory cells offers new insights into dysferlinopathy pathogenesis.
  • Targeting dysferlin's role in immune cells may present novel therapeutic strategies for muscular dystrophies.