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[An update on neuropsychiatric lupus with emphasis in cognitive dysfunction]
Tomás León1, Carla Henríquez, Jorge Calderón
1Departamentos de Inmunología Clínica y Reumatología y Psiquiatría, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Systemic lupus erythematosus (SLE) can cause neuropsychiatric (NP) symptoms, impacting patients physically and psychologically. This review focuses on cognitive dysfunction in NP lupus, exploring causes like antineuronal autoantibodies.
Area of Science:
- Rheumatology
- Neurology
- Immunology
Context:
- Systemic lupus erythematosus (SLE) is associated with diverse neuropsychiatric (NP) symptoms impacting physical and psychological health.
- Established nomenclature and case definitions for NP lupus syndromes exist from the American College of Rheumatology (1999).
Purpose:
- To review the nomenclature and case definitions for neuropsychiatric lupus syndromes.
- To emphasize cognitive dysfunction within NP lupus.
- To discuss etiological hypotheses, particularly the role of antineuronal autoantibodies.
Summary:
- This review examines the established definitions for neuropsychiatric lupus syndromes.
- Cognitive dysfunction is highlighted as a key manifestation of NP lupus.
- Potential causes, including antineuronal autoantibodies, are explored.
Impact:
- Provides a consolidated overview of NP lupus definitions and diagnostic considerations.
- Highlights the significance of cognitive impairment in SLE patients.
- Contributes to understanding the autoimmune basis of neuropsychiatric manifestations in SLE.
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