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Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Sex-linked Disorders01:43

Sex-linked Disorders

Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: May 12, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
07:44

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

[Pediatric germ cell tumours].

Cécile Faure-Conter1, Nathalie Rocourt, Hélène Sudour-Bonnange

  • 1Institut d'hémato-oncologie pédiatrique, département de pédiatrie, 1 place Joseph-Renaut, Lyon cedex 08, France. cecile.conter@lyon.unicancer.fr

Bulletin Du Cancer
|April 6, 2013
PubMed
Summary
This summary is machine-generated.

Germ cell tumors are diverse cancers in children and adolescents, often curable with surgery and chemotherapy. Research explores reducing treatment intensity to minimize long-term side effects.

Keywords:
chemotherapychildrencisplatintumoral markers

Related Experiment Videos

Last Updated: May 12, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
07:44

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

Area of Science:

  • Pediatric Oncology
  • Cancer Biology
  • Tumor Heterogeneity

Context:

  • Germ cell tumors (GCTs) represent 3% of pediatric cancers, with varied clinical and histological presentations.
  • GCTs exhibit bimodal age distribution, peaking in infancy and post-puberty.
  • Sacrococcygeal teratomas and yolk sac tumors dominate infancy, while mixed GCTs are common in adolescents.

Purpose:

  • To review the epidemiology, clinical presentation, and management of pediatric germ cell tumors.
  • To discuss the efficacy of chemotherapy, particularly platinum-based regimens, and surgical approaches.
  • To explore the potential for therapeutic de-escalation and address challenges in recurrent/refractory disease.

Summary:

  • Pediatric germ cell tumors are heterogeneous, with non-seminomatous types predominant.
  • Surgical resection is crucial, often combined with neoadjuvant chemotherapy (especially platinum-based) for sensitive tumors.
  • Prognosis is generally favorable, even in metastatic cases, prompting investigation into de-escalation strategies.

Impact:

  • Highlights the need for conservative yet oncologically sound surgical techniques.
  • Emphasizes the high chemosensitivity of most GCTs, except teratomas.
  • Identifies the challenge of managing recurrent or refractory GCTs and the need for new therapeutic strategies.