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Ginger: is it ready for prime time?
1Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Medical College of Wisconsin, Milwaukee, WI 53226, USA. gstoner@mcw.edu
Cancer Prevention Research (Philadelphia, Pa.)
|April 6, 2013
Summary
Ginger extract may reduce cell proliferation and increase apoptosis in the colon, suggesting potential for colorectal cancer prevention. Further research is needed to confirm these promising findings in high-risk individuals.
Area of Science:
- Gastroenterology
- Cancer Prevention
- Pharmacology
Background:
- Preclinical studies show ginger's preventive potential against cancer.
- A Phase I trial confirmed ginger extract's tolerability in humans.
Purpose of the Study:
- To evaluate ginger extract's effects on biomarkers of cell proliferation, differentiation, and apoptosis in high-risk individuals for colorectal cancer.
Main Methods:
- A pilot trial administered ginger extract (2 g/day for 28 days).
- Biomarkers including human telomerase reverse transcriptase (hTERT), MIB-1, p21waf1/cip1, Bax, and Bcl-2 were analyzed in colonic mucosa.
Main Results:
- Ginger extract suggested reduced proliferation in normal colorectal epithelium.
- Increased apoptosis relative to proliferation was observed, particularly in colon crypt differentiation zones.
Conclusions:
- Pilot data suggest ginger may have chemopreventive effects on colorectal cancer.
- Further studies are recommended, including animal models, pharmacokinetic analysis, and trials in individuals with premalignant conditions.
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